DNA /RNA Sequencing

DNA & RNA Sequencing Services

DNA and RNA sequencing plays a crucial role in biologics, gene therapy, and biosimilar development, enabling researchers to answer a wide range of quality control, process, and development questions. From integration site analysis of gene therapies to the validation of vector genome integrity and monoclonality, sequencing technologies provide essential insights into genome structure, integrity, and stability at every stage of biologics production.

At Biofidus, we provide accurate and reliable nucleic acid analysis using next-generation sequencing (NGS) with Oxford Nanopore Technologies (ONT). This long-read sequencing technology is ideal for addressing complex challenges.

The high-throughput, fast turnaround times, and high-quality data from ONT sequencing allow us to meet the needs of biotech and pharmaceutical companies, supporting the entire drug development cycle, from early discovery through clinical development.

Our team of experts is ready to provide tailored sequencing solutions for your specific needs, ensuring that you get the most accurate, reliable, and actionable data for your biologic or gene therapy project. In line with your needs, we adapt our platform methods to your product, its formulation matrix, and your distinct analytical questions.

Get in contact with us to quickly find the optimal setup for your analytical challenge and to speak directly from expert to expert.

Our Capabilities

  • TCR sequencing
  • 16S sequencing
  • Long read sequencing (ONT)​
  • Genome integrity analysis (truncations, duplications, fusions, etc.)​
  • Amplicon and vector/plasmid characterization​
  • Analysis of repetitive genetic elements​
  • poly(A) characterization
  • Qualitative and quantitative analysis of process-related DNA contaminations​

Just what you need? Contact us!

Oligonucleotide services

Advancing research through tailored bioanalytical solutions.

  • Gene integration site analysis in cell lines or genetically modified organisms
  • Validation of genome integrity of gene therapy vectors
  • Monoclonality assessment to ensure homogeneous cell populations
  • Gene copy number determination
  • Structural analysis of tandem repeats and repetitive sequences
  • Transcriptomics and expression profiling
  • Detection and quantification of host cell DNA impurities

TECHNOLOGIES USED

  1. Oxford Nanopore Technologies sequencing (ONT)
  2. Quantitative PCR (qPCR)

Tell us about Your Project

We‘ll advise you to define your assay needs.

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Our Expert

Please reach out to our expert Dr. Tobias Luttermann for all inquiries concerning DNA or RNA analysis.
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