Spent Media Analysis for Cell Culture & Bioprocess Optimization
To select the optimal cell culture medium and achieve robust, high-yield production, it is crucial to monitor spent media composition over the course of cultivation. Changes in nutrients, metabolites and impurities directly affect cell growth, productivity, product quality and process robustness.
A detailed characterization of spent media compounds – together with the detection of process-related impurities and potentially cytotoxic by-products, forms a fundamental building block for process development, optimization and quality control in upstream bioprocessing.
At Biofidus, we offer standardized chromatographic assays for spent media analysis, covering a broad range of compounds such as amino acids, organic acids, polyamines, surfactants, sugars, fatty acids, vitamins and process-related impurities. The insights gained support medium and feed optimization, scale-up, troubleshooting and continuous process improvement.
In line with your needs, we adapt and, where required, qualify our platform methods according to relevant guidelines, tailoring them to your cell line, process setup and specific analytical questions, from screening experiments to GMP-relevant monitoring strategies.
Get in contact with our expert to find the optimal strategy for your project and to speak directly from scientist to scientist.
